331119 RESULTS
RESEARCH NEWS 2024-04-27 Research News C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because these fragments disrupt calcium flux. In
COMMENT In this elegant study by Bretou et al., new mechanistic evidence is provided for APP-mediated endolysosomal dysfunction in AD. Altered lysosomal Ca2+ levels due to APP-CTF accumulation at the lysosome side of lysosome-ER contact sites appear to be the dri
COMMENT Bretou and the Annaert group report observations on the interplay of calcium, APP-βC-terminal fragments (βCTF), and the endolysosomal system using mainly a mouse embryonic fibroblast cell line that was CRISPR-edited to delete both presenilin 1 and PSEN2.
COMMENT I think this is a beautiful paper with a lot of high-quality cell biology on the role of APP and γ-secretase on endolysosomal function. The authors convincingly show that the inhibition, or loss, of γ-secretase activity results in endolysosomal dysfunctio
COMMENT Previous studies in human neurons have established that mutations in APP and PSEN1 causal for AD result in endolysosomal and autophagy dysfunction as a consequence of reduced turnover of C-terminal fragments of APP (APP-CTFs), and that this is probably a
COMMENT This study provides exciting mechanistic insights into how APP CTFs, and not Aβ, may contribute to the lysosomal dysfunction in Alzheimer’s disease. This cell biological study is comprehensive, carefully conducted, convincing, and in good agreement with p
COMMENT I really enjoy reading papers from the Annaert lab because of their high level of cell biology, which is so needed for our field to better understand the cellular mechanisms underlying AD. This paper by Bretou et al. is a tour de force with diverse and el
PAPER Burgoyne T, Patel S, Eden ER
GRANT Friday, April 26, 2024- 4:30pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-134.html 06 Apr 2027
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-191.html 08 May 2027
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-192.html 08 May 2027
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-193.html 08 May 2027
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-194.html 08 May 2027
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PA-24-195.html 08 May 2027
GRANT Friday, April 26, 2024- 4:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-131.html 06 Apr 2027
